Stem cell differentiation – University of Copenhagen

Uni-Bio Lab > Research > Stem cell differentiation

How do cells communicate and coordinate their fates to arrive at right proportions of differentiated cell types? How flexible/reversible are the transitions between differentiation states? Are there common principles (despite different set of proteins) at different differentiation stages and across organs?  

We address these questions in collaboration with Joshua Brickmann (ES cells, early blastocyst) and Anne Grapin-Botton (pancreas) labs theoretically by in-silico models and experimentally by quantitative single-cell imaging and rna and protein profiling.

Image of the pancreas (center)

Rule-based model of the early embryo development