Stress responses – University of Copenhagen

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Uni-Bio Lab > Research > Stress responses

We strive to quantitatively understand the logic behind stress responses and how it unfolds itself in time and across cells in the tissue. What mechanisms did cells and organisms evolve to deal with the insults that perturb their normal function (stresses)?

What are the differences and similarities between the stress responses? (Both at the level of regulatory network and the dynamics of its components in single cells and on a cell-population level).With this knowledge and with the help of mathematical modeling the hope is to outline the "core circuits" that govern a given process. For this approach we employ a variety of theoretical tools complemented with experimental techniques (e.g. time-lapse of fluorescently tagged proteins in single cells) whenever possible. 

Asymmetric Damage Segregation as population level stress response

Damaged proteins are collected in aggregates (green) in E.coli cells

Part of our current activity is on the stress response processes that are directly involved in diseases:

Dynamics of NF-kB meditated inflammatory response in tissue (Inflammation);

  • Dual roles of IL-1beta in pancreatic islets (with Thomas Mandrup-Poulsen, KU, Panum)

Unfolded Protein Response (Diabetes, with Feroz Papa, UCSF and Chao Tang, PKU);

DNA damage and response to genotoxic stresses, telomeres dynamics (Aging, Cancer)

Bacterial Persistence (Mutli-drug tolerance)